Anti-Cleaved-CASP6-D162 antibody (144-193 aa) (STJ90006)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from mouse Caspase 6 at the amino acid range 144-193
General Information
| Short Description | Rabbit polyclonal anti-Cleaved-CASP6-D162 (144-193 aa) for use in WB, IHC, IF and ELISA in Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Immunogen | The antiserum was produced against synthesized peptide derived from mouse Caspase 6 at the amino acid range 144-193 |
| Immunogen Region | 144-193 aa |
| Specificity | Cleaved-Caspase-6 p18 (D162) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-6 p18 protein resulting from cleavage adjacent to D162. |
Additional Info
| Function | Cysteine protease that plays essential roles in programmed cell death, axonal degeneration, development and innate immunity. During apoptosis, localizes in the nucleus and cleaves the nuclear structural protein NUMA1 and lamin A/LMNA thereby inducing nuclear shrinkage and fragmentation. Furthermore, cleaves many transcription factors such as NF-kappa-B and cAMP response element-binding protein/CREBBP. Plays an essential role in axon degeneration during axon pruning which is the remodeling of axons during neurogenesis but not apoptosis. Regulates B-cell programs both during early development and after antigen stimulation. In addition, promotes the ZBP1-mediated activation of programmed cell death pathways including pyroptosis, apoptosis, and necroptosis (PANoptosis) and plays an essential role in defense against viruses. Mechanistically, interacts with RIPK3 and enhances the interaction between RIPK3 and ZBP1, leading to ZBP1-mediated inflammasome activation and cell death. |
| Protein Name | Caspase-6Casp-6Apoptotic Protease Mch-2 Cleaved Into - Caspase-6 Subunit P18 - Caspase-6 Subunit P11 |
| Database Links | Reactome: R-HSA-111465Reactome: R-HSA-264870Reactome: R-HSA-352238Reactome: R-HSA-6803207 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Caspase-6 antibodyAnti-Casp-6 antibodyAnti-Apoptotic Protease Mch-2 Cleaved Into - Caspase-6 Subunit P18 - Caspase-6 Subunit P11 antibodyAnti-CASP6 antibodyAnti-MCH2 antibody |
Information sourced from Uniprot.org