• Western blot analysis of lysates from 293 cells, treated with etoposide 25uM 1h, using Caspase 5 (p10, Cleaved-Ser331) Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using Cleaved-Caspase-5 p10 (S331) Polyclonal Antibody diluted at 1：1000

Anti-Cleaved-CASP5-S331 antibody (312-361 aa) (STJ90029)

SKU:
STJ90029

£48.00 - £252.00
Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cleaved-Caspase-5-III-S331 (312-361 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CASP5
Gene ID: 838
Uniprot ID: CASP5_HUMAN
Immunogen Region: 312-361 aa
Specificity: Cleaved-Caspase-5 p10 (S331) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-5 p10 protein resulting from cleavage adjacent to S331.
Immunogen: The antiserum was produced against synthesized peptide derived from the human Caspase 5 at the amino acid range 312-361
Post Translational Modifications The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
Function Thiol protease that acts as a mediator of programmed cell death. Initiates pyroptosis, a programmed lytic cell death pathway through cleavage of Gasdermin-D (GSDMD): cleavage releases the N-terminal gasdermin moiety (Gasdermin-D, N-terminal) that binds to membranes and forms pores, triggering pyroptosis. Also mediates cleavage and maturation of IL18. Cleavage of GSDMD and IL18 is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP4. During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation.
Protein Name Caspase-5
Casp-5
Ice(Rel-Iii
Protease Ich-3
Protease Ty Cleaved Into - Caspase-5 Subunit P20 - Caspase-5 Subunit P10
Database Links Reactome: R-HSA-5620971
Alternative Antibody Names Anti-Caspase-5 antibody
Anti-Casp-5 antibody
Anti-Ice(Rel-Iii antibody
Anti-Protease Ich-3 antibody
Anti-Protease Ty Cleaved Into - Caspase-5 Subunit P20 - Caspase-5 Subunit P10 antibody
Anti-CASP5 antibody
Anti-ICH3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance