• Western blot analysis of lysates from HeLa and A549 cells, treated with etoposide 25uM 24h, using Caspase 5 (p20, Cleaved-Asp121) Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using Cleaved-Caspase-5 p20 (D121) Polyclonal Antibody diluted at 1：1000

Anti-Cleaved-CASP5-D121 antibody (102-151 aa) (STJ90030)

SKU:
STJ90030

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cleaved-Caspase-5-III-D121 (102-151 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CASP5
Gene ID: 838
Uniprot ID: CASP5_HUMAN
Immunogen Region: 102-151 aa
Specificity: Cleaved-Caspase-5 p20 (D121) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-5 p20 protein resulting from cleavage adjacent to D121.
Immunogen: The antiserum was produced against synthesized peptide derived from the human Caspase 5 at the amino acid range 102-151
Post Translational Modifications The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
Function Thiol protease that acts as a mediator of programmed cell death. Initiates pyroptosis, a programmed lytic cell death pathway through cleavage of Gasdermin-D (GSDMD): cleavage releases the N-terminal gasdermin moiety (Gasdermin-D, N-terminal) that binds to membranes and forms pores, triggering pyroptosis. During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation.
Protein Name Caspase-5
Casp-5
Ice(Rel-Iii
Protease Ich-3
Protease Ty Cleaved Into - Caspase-5 Subunit P20 - Caspase-5 Subunit P10
Database Links Reactome: R-HSA-5620971
Alternative Antibody Names Anti-Caspase-5 antibody
Anti-Casp-5 antibody
Anti-Ice(Rel-Iii antibody
Anti-Protease Ich-3 antibody
Anti-Protease Ty Cleaved Into - Caspase-5 Subunit P20 - Caspase-5 Subunit P10 antibody
Anti-CASP5 antibody
Anti-ICH3 antibody

Information sourced from Uniprot.org

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