| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Cleaved-Complement C1s subcomponent-Ile438, Light Chain (437-438) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
C1S |
| Gene ID: |
716 |
| Uniprot ID: |
C1S_HUMAN |
| Immunogen Region: |
437-438 |
| Specificity: |
This antibody detects endogenous levels of Human C1S (light chain, Cleaved-Ile438, protein was cleaved amino acid sequence between 437-438 ) |
| Immunogen: |
Synthesized peptide derived from human C1S (light chain, Cleaved-Ile438) |
| Post Translational Modifications | The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. |
| Function | C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4. Cleaves also IGFBP5 and thereby inhibits the trophic effects of IGF1. |
| Protein Name | Complement C1s SubcomponentC1 EsteraseComplement Component 1 Subcomponent S Cleaved Into - Complement C1s Subcomponent Heavy Chain - Complement C1s Subcomponent Light Chain |
| Database Links | Reactome: R-HSA-166663Reactome: R-HSA-173623Reactome: R-HSA-977606 |
| Alternative Antibody Names | Anti-Complement C1s Subcomponent antibodyAnti-C1 Esterase antibodyAnti-Complement Component 1 Subcomponent S Cleaved Into - Complement C1s Subcomponent Heavy Chain - Complement C1s Subcomponent Light Chain antibodyAnti-C1S antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
