| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Cleaved-Disintegrin and metalloproteinase domain-containing protein 12-Glu208 (207-208) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ADAM12 |
| Gene ID: |
8038 |
| Uniprot ID: |
ADA12_HUMAN |
| Immunogen Region: |
207-208 |
| Specificity: |
This antibody detects endogenous levels of Human, Mouse ADAM 12 (Cleaved-Glu208, protein was cleaved amino acid sequence between 207-208) |
| Immunogen: |
Synthesized peptide derived from human ADAM 12 (Cleaved-Glu208) |
| Tissue Specificity | Isoform 1 is expressed in placenta and skeletal, cardiac, and smooth muscle. Isoform 2 seems to be expressed only in placenta or in embryo and fetus. Both forms were expressed in some tumor cells lines. Not detected in brain, lung, liver, kidney or pancreas. |
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. |
| Function | Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors. |
| Protein Name | Disintegrin And Metalloproteinase Domain-Containing Protein 12Adam 12Meltrin-Alpha |
| Database Links | Reactome: R-HSA-177929Reactome: R-HSA-8941237 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: SecretedIsoform 3: SecretedIsoform 4: Secreted |
| Alternative Antibody Names | Anti-Disintegrin And Metalloproteinase Domain-Containing Protein 12 antibodyAnti-Adam 12 antibodyAnti-Meltrin-Alpha antibodyAnti-ADAM12 antibodyAnti-MLTN antibodyAnti-UNQ346 antibodyAnti-PRO545 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
