Anti-CLDN2 antibody (181-230 aa) (STJ92312)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human Claudin 2 at the amino acid range 181-230
General Information
| Short Description | Rabbit polyclonal anti-Claudin-2 (181-230 aa) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLDN2 |
| Gene ID | 9075 |
| Uniprot ID | CLD2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human Claudin 2 at the amino acid range 181-230 |
| Immunogen Region | 181-230 aa |
| Specificity | Claudin-2 Polyclonal Antibody detects endogenous levels of Claudin-2 protein. |
Additional Info
| Function | Forms paracellular channels: polymerizes in tight junction strands with cation- and water-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability. In intestinal epithelium, allows for sodium and water fluxes from the peritoneal side to the lumen of the intestine to regulate nutrient absorption and clear enteric pathogens as part of mucosal immune response. In kidney, allows passive sodium and calcium reabsorption across proximal tubules from the lumen back to the bloodstream. In the hepatobiliary tract, allows paracellular water and cation fluxes in the hepatic perivenous areas and biliary epithelium to generate bile flow and maintain osmotic gradients. |
| Protein Name | Claudin-2Sp82 |
| Database Links | Reactome: R-HSA-420029 |
| Cellular Localisation | Cell JunctionTight JunctionCell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Claudin-2 antibodyAnti-Sp82 antibodyAnti-CLDN2 antibodyAnti-PSEC0059 antibodyAnti-SP82 antibodyAnti-UNQ705 antibodyAnti-PRO1356 antibody |
Information sourced from Uniprot.org