Anti-CLCC1 antibody (391-440 aa) (STJ92327)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human CLCC1 at the amino acid range 391-440
General Information
| Short Description | Rabbit polyclonal anti-Chloride channel CLIC-like protein 1 (391-440 aa) for use in WB, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IF 1:200-1:1000ELISA 1:40000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLCC1 |
| Gene ID | 23155 |
| Uniprot ID | CLCC1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human CLCC1 at the amino acid range 391-440 |
| Immunogen Region | 391-440 aa |
| Specificity | CLCC1 Polyclonal Antibody detects endogenous levels of CLCC1 protein. |
Additional Info
| Function | Anion-selective channel with Ca(2+)-dependent and voltage-independent gating. Permeable to small monovalent anions with selectivity for bromide > chloride > nitrate > fluoride. Operates in the endoplasmic reticulum (ER) membrane where it mediates chloride efflux to compensate for the loss of positive charges from the ER lumen upon Ca(2+) release. Contributes to the maintenance of ER Ca(2+) pools and activation of unfolded protein response to prevent accumulation of misfolded proteins in the ER lumen. Particularly involved in ER homeostasis mechanisms underlying motor neurons and retinal photoreceptors survival. |
| Protein Name | Chloride Channel Clic-Like Protein 1Er Anion Channel 1Erac1Mid-1-Related Chloride Channel Protein |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinWithin The Endoplasmic Reticulum (Er)Localizes To The Mitochondria-Associated Er MembraneA Zone Of Contact Between The Er And Mitochondrial MembranesEnriched In The Rough Er |
| Alternative Antibody Names | Anti-Chloride Channel Clic-Like Protein 1 antibodyAnti-Er Anion Channel 1 antibodyAnti-Erac1 antibodyAnti-Mid-1-Related Chloride Channel Protein antibodyAnti-CLCC1 antibodyAnti-KIAA0761 antibodyAnti-MCLC antibody |
Information sourced from Uniprot.org