• Western blot analysis of the lysates from HT-29 cells using CLCC1 antibody.
  • Western blot analysis of lysates from COLO and HepG2 cells, using CLCC1 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of HepG2 cells using CLCC1 Polyclonal Antibody diluted at 1：1000
  • Immunofluorescence analysis of A549 cells, using CLCC1 Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using CLCC1 Polyclonal Antibody diluted at 1：1000

Anti-CLCC1 antibody (391-440 aa) (STJ92327)

SKU:
STJ92327

£48.00 - £252.00
Current Stock:
Host: Rabbit
Applications: WB/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Chloride channel CLIC-like protein 1 (391-440 aa) is suitable for use in Western Blot, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IF 1:200-1:1000
ELISA 1:40000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CLCC1
Gene ID: 23155
Uniprot ID: CLCC1_HUMAN
Immunogen Region: 391-440 aa
Specificity: CLCC1 Polyclonal Antibody detects endogenous levels of CLCC1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human CLCC1 at the amino acid range 391-440
Function Anion-selective channel with Ca(2+)-dependent and voltage-independent gating. Permeable to small monovalent anions with selectivity for bromide > chloride > nitrate > fluoride. Operates in the endoplasmic reticulum (ER) membrane where it mediates chloride efflux to compensate for the loss of positive charges from the ER lumen upon Ca(2+) release. Contributes to the maintenance of ER Ca(2+) pools and activation of unfolded protein response to prevent accumulation of misfolded proteins in the ER lumen. Particularly involved in ER homeostasis mechanisms underlying motor neurons and retinal photoreceptors survival.
Protein Name Chloride Channel Clic-Like Protein 1
Er Anion Channel 1
Erac1
Mid-1-Related Chloride Channel Protein
Cellular Localisation Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Within The Endoplasmic Reticulum (Er)
Localizes To The Mitochondria-Associated Er Membrane
A Zone Of Contact Between The Er And Mitochondrial Membranes
Enriched In The Rough Er
Alternative Antibody Names Anti-Chloride Channel Clic-Like Protein 1 antibody
Anti-Er Anion Channel 1 antibody
Anti-Erac1 antibody
Anti-Mid-1-Related Chloride Channel Protein antibody
Anti-CLCC1 antibody
Anti-KIAA0761 antibody
Anti-MCLC antibody

Information sourced from Uniprot.org

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