| Host: |
Rabbit |
| Applications: |
WB/IHC-P/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLCC1 |
| Gene ID: |
23155 |
| Uniprot ID: |
CLCC1_HUMAN |
| Immunogen Region: |
302-501 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 302-501 of human CLCC1 (NP_055942.1). |
| Immunogen Sequence: |
GAGKSVHVLRHIGGPESEPP QALRPRDRRRQEEIDYRPDG GAGDADFHYRGQMGPTEQGP YAKTYEGRREILRERDVDLR FQTGNKSPEVLRAFDVPDAE AREHPTVVPSHKSPVLDTKP KETGGILGEGTPKESSTESS QSAKPVSGQDTSGNTEGSPA AEKAQLKSEAAGSPDQGSTY SPARGVAGPRGQDPVSSPCG |
| Tissue Specificity | Expressed in the retina of the eye, with extensive expression in the lamina cribrosa, optic nerve, ganglion cell layer, inner nuclear layer, outer nuclear layer and retinal pigment epithelium. |
| Function | Anion-selective channel with Ca(2+)-dependent and voltage-independent gating. Permeable to small monovalent anions with selectivity for bromide > chloride > nitrate > fluoride. Operates in the endoplasmic reticulum (ER) membrane where it mediates chloride efflux to compensate for the loss of positive charges from the ER lumen upon Ca(2+) release. Contributes to the maintenance of ER Ca(2+) pools and activation of unfolded protein response to prevent accumulation of misfolded proteins in the ER lumen. Particularly involved in ER homeostasis mechanisms underlying motor neurons and retinal photoreceptors survival. |
| Protein Name | Chloride Channel Clic-Like Protein 1Er Anion Channel 1Erac1Mid-1-Related Chloride Channel Protein |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinWithin The Endoplasmic Reticulum (Er)Localizes To The Mitochondria-Associated Er MembraneA Zone Of Contact Between The Er And Mitochondrial MembranesEnriched In The Rough Er |
| Alternative Antibody Names | Anti-Chloride Channel Clic-Like Protein 1 antibodyAnti-Er Anion Channel 1 antibodyAnti-Erac1 antibodyAnti-Mid-1-Related Chloride Channel Protein antibodyAnti-CLCC1 antibodyAnti-KIAA0761 antibodyAnti-MCLC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
