| Tissue Specificity | Expressed in the retina of the eye, with extensive expression in the lamina cribrosa, optic nerve, ganglion cell layer, inner nuclear layer, outer nuclear layer and retinal pigment epithelium. |
| Function | Anion-selective channel with Ca(2+)-dependent and voltage-independent gating. Permeable to small monovalent anions with selectivity for bromide > chloride > nitrate > fluoride. Operates in the endoplasmic reticulum (ER) membrane where it mediates chloride efflux to compensate for the loss of positive charges from the ER lumen upon Ca(2+) release. Contributes to the maintenance of ER Ca(2+) pools and activation of unfolded protein response to prevent accumulation of misfolded proteins in the ER lumen. Particularly involved in ER homeostasis mechanisms underlying motor neurons and retinal photoreceptors survival. |
| Protein Name | Chloride Channel Clic-Like Protein 1Er Anion Channel 1Erac1Mid-1-Related Chloride Channel Protein |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinWithin The Endoplasmic Reticulum (Er)Localizes To The Mitochondria-Associated Er MembraneA Zone Of Contact Between The Er And Mitochondrial MembranesEnriched In The Rough Er |
| Alternative Antibody Names | Anti-Chloride Channel Clic-Like Protein 1 antibodyAnti-Er Anion Channel 1 antibodyAnti-Erac1 antibodyAnti-Mid-1-Related Chloride Channel Protein antibodyAnti-CLCC1 antibodyAnti-KIAA0761 antibodyAnti-MCLC antibody |
Information sourced from Uniprot.org
