Anti-Claudin 4 antibody [4A10-7F7-4D8] (STJA0033513)

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STJA0033513
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Host: Mouse
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal anti-Claudin 4 for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Monoclonal
Clone ID : 4A10-7F7-4D8
Conjugation: Unconjugated
Isotype: IgG2b
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Purification: Affinity Chromatography
Concentration: 1 mg/mL
Dilution Range: IHC 1:100-1:500
Storage Instruction: Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol: CLDN4
Gene ID: 1364
Uniprot ID: CLD4_HUMAN
Immunogen: Synthesized peptide derived from human Claudin 4
Post Translational Modifications Phosphorylated. Phosphorylation by EPHA2 is stimulated by EFNA1 and alters interaction with TJP1.
Function Can associate with other claudins to regulate tight junction structural and functional strand dynamics. May coassemble with CLDN8 into tight junction strands containing anion-selective channels that convey paracellular chloride permeability in renal collecting ducts. May integrate into CLDN3 strands to modulate localized tight junction barrier properties. May disrupt strand assembly of channel-forming CLDN2 and CLDN15 and inhibit cation conductance. Cannot form tight junction strands on its own.
Protein Name Claudin-4
Clostridium Perfringens Enterotoxin Receptor
Cpe-R
Cpe-Receptor
Williams-Beuren Syndrome Chromosomal Region 8 Protein
Database Links Reactome: R-HSA-420029
Cellular Localisation Cell Junction
Tight Junction
Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Claudin-4 antibody
Anti-Clostridium Perfringens Enterotoxin Receptor antibody
Anti-Cpe-R antibody
Anti-Cpe-Receptor antibody
Anti-Williams-Beuren Syndrome Chromosomal Region 8 Protein antibody
Anti-CLDN4 antibody
Anti-CPER antibody
Anti-CPETR1 antibody
Anti-WBSCR8 antibody

Information sourced from Uniprot.org

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