| Host: | Rabbit |
| Applications: | WB/IP/IF/ICC/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | SRM15070 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Purification: | Affinity purification |
| Dilution Range: | WB, 1:5000-1:30000IP, 0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsIF/ICC, 1:200-1:1000IHC-P, 1:1500-1:6000ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CLTC |
| Gene ID: | 1213 |
| Uniprot ID: | CLH1_HUMAN |
| Immunogen: | Synthetic peptide. This information is considered to be commercially sensitive. |
| Function | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Plays a role in early autophagosome formation. Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating. |
| Protein Name | Clathrin Heavy Chain 1Clathrin Heavy Chain On Chromosome 17Clh-17 |
| Database Links | Reactome: R-HSA-168275Reactome: R-HSA-177504Reactome: R-HSA-190873Reactome: R-HSA-196025Reactome: R-HSA-2132295 Q00610-1Reactome: R-HSA-3928665Reactome: R-HSA-432720 Q00610-1Reactome: R-HSA-432722 Q00610-1Reactome: R-HSA-437239Reactome: R-HSA-5099900Reactome: R-HSA-5140745Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-8866427Reactome: R-HSA-8964038Reactome: R-HSA-9013420Reactome: R-HSA-9013424Reactome: R-HSA-9700645Reactome: R-HSA-9725370 |
| Cellular Localisation | Cytoplasmic Vesicle MembranePeripheral Membrane ProteinCytoplasmic SideMembraneCoated PitMelanosomeCytoplasmCytoskeletonSpindleCytoplasmic Face Of Coated Pits And VesiclesIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage IvIn Complex With Tacc3 And Ckap5 (Forming The Tacc3/Ch-Tog/Clathrin Complex) Localized To Inter-Microtubule Bridges In Mitotic Spindles |
| Alternative Antibody Names | Anti-Clathrin Heavy Chain 1 antibodyAnti-Clathrin Heavy Chain On Chromosome 17 antibodyAnti-Clh-17 antibodyAnti-CLTC antibodyAnti-CLH17 antibodyAnti-CLTCL2 antibodyAnti-KIAA0034 antibody |
Information sourced from Uniprot.org
