| Post Translational Modifications | Methylated. Trimethylation at Lys-395 by CSKMT decreases citrate synthase activity. In response to mitochondrial stress, the precursor protein is ubiquitinated by the SIFI complex in the cytoplasm before mitochondrial import, leading to its degradation. Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1. |
| Function | Key enzyme of the Krebs tricarboxylic acid cycle which catalyzes the synthesis of citrate from acetyl coenzyme A and oxaloacetate. |
| Protein Name | Citrate Synthase - MitochondrialCitrateSi-Synthase |
| Database Links | Reactome: R-HSA-1268020Reactome: R-HSA-71403Reactome: R-HSA-9837999Reactome: R-HSA-9854311 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Citrate Synthase - Mitochondrial antibodyAnti-Citrate antibodyAnti-Si-Synthase antibodyAnti-CS antibody |
Information sourced from Uniprot.org
