| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CISH (1-257) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CISH |
| Gene ID: |
1154 |
| Uniprot ID: |
CISH_HUMAN |
| Immunogen Region: |
1-257 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-257 of human CISH (NP_659508.1). |
| Immunogen Sequence: |
MVLCVQGPRPLLAVERTGQR PLWAPSLELPKPVMQPLPAG AFLEEVAEGTPAQTESEPKV LDPEEDLLCIAKTFSYLRES GWYWGSITASEARQHLQKMP EGTFLVRDSTHPSYLFTLSV KTTRGPTNVRIEYADSSFRL DSNCLSRPRILAFPDVVSLV QHYVASCTADTRSDSPDPAP TPALPMPKEDAPSDPALPAP PPATAVHLKLVQPFVRRSSA RSLQHLCRLVINRLVADVD |
| Tissue Specificity | Expressed in various epithelial tissues. Abundantly expressed in liver and kidney, and to a lesser extent in lung. The tissue distribution of isoforms 1 and 1B is distinct. |
| Post Translational Modifications | Association with EPOR may target the protein for proteolysis by the ubiquitin-dependent proteasome pathway. CIS is mainly monubiquitinated (37 kDa form) but may also exist in a polyubiquitinated form (45 kDa). |
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
| Protein Name | Cytokine-Inducible Sh2-Containing ProteinCisCis-1Protein G18Suppressor Of Cytokine SignalingSocs |
| Database Links | Reactome: R-HSA-1266695Reactome: R-HSA-8951664Reactome: R-HSA-982772 |
| Alternative Antibody Names | Anti-Cytokine-Inducible Sh2-Containing Protein antibodyAnti-Cis antibodyAnti-Cis-1 antibodyAnti-Protein G18 antibodyAnti-Suppressor Of Cytokine Signaling antibodyAnti-Socs antibodyAnti-CISH antibodyAnti-G18 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
