Anti-CINP antibody (1-212) (STJ11104225)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal Cyclin-Dependent Kinase 2-Interacting Protein (1-212) antibody for use in WB and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CINP |
| Gene ID | 51550 |
| Uniprot ID | CINP_HUMAN |
| Immunogen Region | 1-212 |
| Immunogen Sequence | MEAKTLGTVTPRKPVLSVSA RKIKDNAADWHNLILKWETL NDAGFTTANNIANLKISLLN KDKIELDSSSPASKENEEKV CLEYNEELEKLCEELQATLD GLTKIQVKMEKLSSTTKGIC ELENYHYGEESKRPPLFHTW PTTHFYEVSHKLLEMYRKEL LLKRTVAKELAHTGDPDLTL SYLSMWLHQPYVESDSRLHL ESMLLETGHRAL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-212 of human CINP (NP_116019.1). |
Additional Info
| Post Translational Modifications | Phosphorylated by CDC7 but not by CDK2. |
| Function | Component of the DNA replication complex, which interacts with two kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling in response to DNA damage. Part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity. As part of 55LCC complex, also involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles. |
| Protein Name | Cyclin-Dependent Kinase 2-Interacting ProteinCdk2-Interacting Protein |
| Database Links | |
| Cellular Localisation | NucleusBinds To Nuclear Under G1 ConditionsAnd Dissociates From Chromatin With The Start Of Dna Replication |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase 2-Interacting Protein antibodyAnti-Cdk2-Interacting Protein antibodyAnti-CINP antibody |
Information sourced from Uniprot.org