Anti-CIDEA antibody (20-219) (STJ29969)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CIDEA (20-219) antibody for use in WB, IHC-P and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CIDEA |
| Gene ID | 1149 |
| Uniprot ID | CIDEA_HUMAN |
| Immunogen Region | 20-219 |
| Immunogen Sequence | SQTKRVLFTPLMHPARPFRV SNHDRSSRRGVMASSLQELI SKTLDALVIATGLVTLVLEE DGTVVDTEEFFQTLGDNTHF MILEKGQKWMPGSQHVPTCS PPKRSGIARVTFDLYRLNPK DFIGCLNVKATMYEMYSVSY DIRCTGLKGLLRSLLRFLSY SAQVTGQFLIYLGTYMLRVL DDKEERPSLRSQAKGRFTCG |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 20-219 of human CIDEA (NP_001270.1). |
Additional Info
| Tissue Specificity | Expressed in omental and subcutaneous adipose tissue (at protein level). |
| Function | Lipid transferase that promotes unilocular lipid droplet formation by mediating lipid droplet fusion. Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage. Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by promoting directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. May also act as a CEBPB coactivator in epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter. When overexpressed, induces apoptosis.the physiological significance of its role in apoptosis is unclear. |
| Protein Name | Lipid Transferase CideaCell Death Activator Cide-ACell Death-Inducing Dffa-Like Effector A |
| Database Links | Reactome: R-HSA-8964572Reactome: R-HSA-9844594 |
| Cellular Localisation | Lipid DropletNucleusEnriched At Lipid Droplet Contact Sites |
| Alternative Antibody Names | Anti-Lipid Transferase Cidea antibodyAnti-Cell Death Activator Cide-A antibodyAnti-Cell Death-Inducing Dffa-Like Effector A antibodyAnti-CIDEA antibody |
Information sourced from Uniprot.org