| Background | Chromogranin A is localized in secretory granules of neurons and endocrine cells in tissues, including pituitary, adrenal medulla, thyroid, pancreatic islets, and the gastrointestinal tract. Neuroendocrine cells exhibit a fine granular immunoreactivity to Anti-Chromogranin A. It is widely recognized that co-expression of keratins and chromogranin A implies a neuroendocrine lineage. High expression of chromogranin A and negative staining with Anti-Keratin is a possible indication of paraganglioma. Positive staining for chromogranin A and neuron-specific enolase is representative of neuroendocrine neoplasms. Many pituitary adenomas and prolactinomas stain positively for chromogranin A. |
Information sourced from Uniprot.org
![Anti-Chromogranin A antibody [5H7] (STJ16101718)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/152224/347076/STJ16101718_1__76856.1681999337.jpg?c=1 "Anti-Chromogranin A antibody [5H7] (STJ16101718)")