| Host: | Rabbit |
| Applications: | WB/IF/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CHRNA4 |
| Gene ID: | 1137 |
| Uniprot ID: | ACHA4_HUMAN |
| Immunogen Region: | 29-242 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-242 of human ACHA4 (P43681). |
| Immunogen Sequence: | HVETRAHAEERLLKKLFSGY NKWSRPVANISDVVLVRFGL SIAQLIDVDEKNQMMTTNVW VKQEWHDYKLRWDPADYENV TSIRIPSELIWRPDIVLYNN ADGDFAVTHLTKAHLFHDGR VQWTPPAIYKSSCSIDVTFF PFDQQNCTMKFGSWTYDKAK IDLVNMHSRVDQLDFWESGE WVIVDAVGTYNTRKYECCAE IYPDITYAFVIRRL |
| Function | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions. |
| Protein Name | Neuronal Acetylcholine Receptor Subunit Alpha-4 |
| Database Links | Reactome: R-HSA-629587Reactome: R-HSA-629594Reactome: R-HSA-629597 |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane ProteinCell MembraneLipid-Anchor |
| Alternative Antibody Names | Anti-Neuronal Acetylcholine Receptor Subunit Alpha-4 antibodyAnti-CHRNA4 antibodyAnti-NACRA4 antibody |
Information sourced from Uniprot.org