| Short Description : | Rabbit polyclonal CHRNA2 (27-264) antibody for use in WB and ELISA in rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CHRNA2 |
| Gene ID: | 1135 |
| Uniprot ID: | ACHA2_HUMAN |
| Immunogen Region: | 27-264 |
| Immunogen Sequence: | EEAKRPPPRAPGDPLSSPSP TALPQGGSHTETEDRLFKHL FRGYNRWARPVPNTSDVVIV RFGLSIAQLIDVDEKNQMMT TNVWLKQEWSDYKLRWNPTD FGNITSLRVPSEMIWIPDIV LYNNADGEFAVTHMTKAHLF STGTVHWVPPAIYKSSCSID VTFFPFDQQNCKMKFGSWTY DKAKIDLEQMEQTVDLKDYW ESGEWAIVNATGTYNSKKYD CCAEIYPDVTYAFVIRRL |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-264 of human CHRNA2 (NP_000733.2). |
| Function | Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNA2 forms heteropentameric neuronal acetylcholine receptors with CHRNB2 and CHRNB4 and plays a role in nicotine dependence. |
| Protein Name | Neuronal Acetylcholine Receptor Subunit Alpha-2Nicotinic Acetylcholine Receptor Subunit Alpha-2 |
| Database Links | Reactome: R-HSA-629594Reactome: R-HSA-629597 |
| Cellular Localisation | Synaptic Cell MembraneMulti-Pass Membrane ProteinCell Membrane |
| Alternative Antibody Names | Anti-Neuronal Acetylcholine Receptor Subunit Alpha-2 antibodyAnti-Nicotinic Acetylcholine Receptor Subunit Alpha-2 antibodyAnti-CHRNA2 antibody |
Information sourced from Uniprot.org
