Anti-CHRM2 nanobody [SAA0920] (STJN000121)

Anti-CHRM2 nanobody [SAA0920] (STJN000121)

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STJN000121
£378.50 - £1,632.50
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Host: Alpaca
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Alpaca monoclonal nanobody anti-Muscarinic Acetylcholine Receptor M2 is suitable for use in ELISA research applications.
Clonality : Monoclonal
Clone ID : SAA0920
Conjugation: Unconjugated
Isotype: VHH-8His-Cys-tag
Formulation: 0.01M PBS, pH 7.4.
Purification: Purified by Nickel column.
Concentration: 1 mg/mL
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol: CHRM2
Gene ID: 1129
Uniprot ID: ACM2_HUMAN
Function The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3).this then triggers calcium ion release into the cytosol.
Protein Name Muscarinic Acetylcholine Receptor M2
Database Links Reactome: R-HSA-390648
Reactome: R-HSA-418594
Reactome: R-HSA-8856825
Reactome: R-HSA-8856828
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Postsynaptic Cell Membrane
Phosphorylation In Response To Agonist Binding Promotes Receptor Internalization
Alternative Nanobody Names Anti-Muscarinic Acetylcholine Receptor M2 nanobody
Anti-CHRM2 nanobody

Information sourced from Uniprot.org

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