Anti-CHRM2 antibody (208-388) (STJ23131)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CHRM2 (208-388) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CHRM2 |
| Gene ID | 1129 |
| Uniprot ID | ACM2_HUMAN |
| Immunogen Region | 208-388 |
| Immunogen Sequence | HISRASKSRIKKDKKEPVAN QDPVSPSLVQGRIVKPNNNN MPSSDDGLEHNKIQNGKAPR DPVTENCVQGEEKESSNDST SVSAVASNMRDDEITQDENT VSTSLGHSKDENSKQTCIRI GTKTPKSDSCTPTNTTVEVV GSSGQNGDEKQNIVARKIVK MTKQPAKKKPPPSREKKVTR T |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 208-388 of human Muscarinic AChR M2 (ACM2) (NP_001006629.1). |
Additional Info
| Post Translational Modifications | Phosphorylated in response to agonist treatment. |
| Function | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3).this then triggers calcium ion release into the cytosol. |
| Protein Name | Muscarinic Acetylcholine Receptor M2 |
| Database Links | Reactome: R-HSA-390648Reactome: R-HSA-418594Reactome: R-HSA-8856825Reactome: R-HSA-8856828 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell MembranePhosphorylation In Response To Agonist Binding Promotes Receptor Internalization |
| Alternative Antibody Names | Anti-Muscarinic Acetylcholine Receptor M2 antibodyAnti-CHRM2 antibody |
Information sourced from Uniprot.org