| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CHRM2 |
| Gene ID: | 1129 |
| Uniprot ID: | ACM2_HUMAN |
| Immunogen Region: | 208-388 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 208-388 of human Muscarinic AChR M2 (ACM2) (NP_001006629.1). |
| Immunogen Sequence: | HISRASKSRIKKDKKEPVAN QDPVSPSLVQGRIVKPNNNN MPSSDDGLEHNKIQNGKAPR DPVTENCVQGEEKESSNDST SVSAVASNMRDDEITQDENT VSTSLGHSKDENSKQTCIRI GTKTPKSDSCTPTNTTVEVV GSSGQNGDEKQNIVARKIVK MTKQPAKKKPPPSREKKVTR T |
| Post Translational Modifications | Phosphorylated in response to agonist treatment. |
| Function | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3).this then triggers calcium ion release into the cytosol. |
| Protein Name | Muscarinic Acetylcholine Receptor M2 |
| Database Links | Reactome: R-HSA-390648Reactome: R-HSA-418594Reactome: R-HSA-8856825Reactome: R-HSA-8856828 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell MembranePhosphorylation In Response To Agonist Binding Promotes Receptor Internalization |
| Alternative Antibody Names | Anti-Muscarinic Acetylcholine Receptor M2 antibodyAnti-CHRM2 antibody |
Information sourced from Uniprot.org
