Anti-CHRDL1 antibody [3H1-F6-A10] (STJ99125)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenPurified recombinant human CHRDL1 protein fragments expressed in E.coli.
General Information
| Short Description | Mouse monoclonal anti-Chordin-like protein 1 for use in WB, IHC and ICC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/ICC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 3H1-F6-A10 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000IHC-P 1:300ICC 1:300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CHRDL1 |
| Gene ID | 91851 |
| Uniprot ID | CRDL1_HUMAN |
| Immunogen | Purified recombinant human CHRDL1 protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of CHRDL1 and does not cross-react with related proteins. |
Additional Info
| Function | Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation. May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development. |
| Protein Name | Chordin-Like Protein 1Neuralin-1Neurogenesin-1Ventroptin |
| Database Links | Reactome: R-HSA-201451Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Chordin-Like Protein 1 antibodyAnti-Neuralin-1 antibodyAnti-Neurogenesin-1 antibodyAnti-Ventroptin antibodyAnti-CHRDL1 antibodyAnti-NRLN1 antibody |
Information sourced from Uniprot.org