Anti-CHMP7 antibody (230-453) (STJ116572)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CHMP7 (230-453) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CHMP7 |
| Gene ID | 91782 |
| Uniprot ID | CHMP7_HUMAN |
| Immunogen Region | 230-453 |
| Immunogen Sequence | KVSPVNDVDVGVYQLMQSEQ LLSRKVESLSQEAERCKEEA RRACRAGKKQLALRSLKAKQ RTEKRIEALHAKLDTVQGIL DRIYASQTDQMVFNAYQAGV GALKLSMKDVTVEKAESLVD QIQELCDTQDEVSQTLAGGV TNGLDFDSEELEKELDILLQ DTTKEPLDLPDNPRNRHFTN SVPNPRISDAELEAELEKLS LSEGGLVPSSKSPKRQLEPT LKPL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 230-453 of human CHMP7 (NP_689485.1). |
Additional Info
| Function | ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope (NE) during late anaphase. Together with SPAST, the ESCRT-III complex promotes NE sealing and mitotic spindle disassembly during late anaphase. Recruited to the reforming NE during anaphase by LEMD2. Plays a role in the endosomal sorting pathway. |
| Protein Name | Charged Multivesicular Body Protein 7Chromatin-Modifying Protein 7 |
| Database Links | Reactome: R-HSA-162588Reactome: R-HSA-1632852Reactome: R-HSA-5620971Reactome: R-HSA-917729Reactome: R-HSA-9610379Reactome: R-HSA-9615710Reactome: R-HSA-9668328Reactome: R-HSA-9679504Reactome: R-HSA-9694676 |
| Cellular Localisation | CytoplasmNucleus EnvelopeDiffused LocalizationWith Some Punctate DistributionEspecially In The Perinuclear AreaLocalizes To The Reforming Nuclear Envelope On Chromatin Disks During Late Anaphase |
| Alternative Antibody Names | Anti-Charged Multivesicular Body Protein 7 antibodyAnti-Chromatin-Modifying Protein 7 antibodyAnti-CHMP7 antibody |
Information sourced from Uniprot.org