Anti-CHM antibody (617 to C-Term) (STJ140142)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
ImmunogenPurified recombinant peptide derived from within residues 617 aa-stop at the C-terminus of human Rep1 produced in E. coli.
General Information
| Short Description | Goat polyclonal Choroideremia (Rab escort protein 1) (617 to C-Term) antibody for use in WB in human, mouse, rat, bovine, canine, chicken, avian, donkey, feline, goat, guinea pig, hamster, horse, porcine, rabbit, sheep and simian samples. Datasheet i |
| Applications | WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Bovine/Canine/Chicken/Avian/Donkey/Feline/Goat/Guinea Pig/Hamster/Horse/Porcine/Rabbit/Sheep/Simian |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 4 mg/mL |
| Purification | This antibody is epitope-affinity purified from goat antiserum. |
| Dilution Range | WB 1:500-1:2000 |
| Formulation | PBS, 20% Glycerol and 0.05% Sodium Azide. |
| Storage Instruction | For continuous use, store at 2-8 C for one-two days. For extended storage, store in-20 C freezer. Working dilution samples should be discarded if not used within 12 hours. |
Target Information
| Gene Symbol | CHM |
| Gene ID | 1121 |
| Uniprot ID | RAE1_HUMAN |
| Accession Number | ENSG00000188419 |
| Immunogen | Purified recombinant peptide derived from within residues 617 aa-stop at the C-terminus of human Rep1 produced in E. coli. |
| Immunogen Region | 617 to C-Term |
| Immunogen Sequence | IIFDGDSLQPEASESSAIPE IFDGDSLQPEASESSAIPEA |
| Specificity | Detects endogenous Rep1 and in transfected cells by Western blot. |
Additional Info
| Function | Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins.this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation. |
| Protein Name | Rab Proteins Geranylgeranyltransferase Component A 1Choroideremia ProteinRab Escort Protein 1Rep-1Tcd Protein |
| Database Links | Reactome: R-HSA-6803205Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Rab Proteins Geranylgeranyltransferase Component A 1 antibodyAnti-Choroideremia Protein antibodyAnti-Rab Escort Protein 1 antibodyAnti-Rep-1 antibodyAnti-Tcd Protein antibodyAnti-CHM antibodyAnti-REP1 antibodyAnti-TCD antibody |
Information sourced from Uniprot.org