| Function | Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication.the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152.however, this function has been questioned. Also recruits CDK1 to centrosomes. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes.this leads to the inactivation of spindle assembly and delay in mitotic progression. Promotes stabilization of FXR1 protein by inhibiting FXR1 ubiquitination. |
| Protein Name | Centrosomal Protein Of 63 KdaCep63 |
| Database Links | Reactome: R-HSA-2565942Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-8854518 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCentrioleCentriolar SatelliteColocalizes With Cdk5rap2Cep152 And Wdr62 In A Discrete Ring Around The Proximal End Of The Parental CentrioleAt This SiteA Cohesive Structure Is Predicted To Engage Parental Centrioles And Procentrioles |
| Alternative Antibody Names | Anti-Centrosomal Protein Of 63 Kda antibodyAnti-Cep63 antibodyAnti-CEP63 antibody |
Information sourced from Uniprot.org
