| Post Translational Modifications | Phosphorylation at Ser-186 is induced upon DNA-damage caused by treatment with IR irradiation, UV irradiation, hydroxyurea or amphidicolin. Also MDC1-mediated chromatin remodeling is critical for DNA damage-induced phosphorylation. |
| Function | Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. |
| Protein Name | Centrosomal Protein Of 164 KdaCep164 |
| Database Links | Reactome: R-HSA-2565942Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-8854518 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCentrioleNucleusLocalizes Specifically To Very Distally Located Appendage Structures On The Mature Centriole From Which Initiate Pc FormationPersisted At Centrioles Throughout MitosisExpressed In Chromatin-Enriched Nuclear Fraction Of Hela CellsIn Response To Dna DamageIt Translocates To Nuclear Foci That Contain The Dna Damage Response Proteins Kat5/Tip60 And Chek1 |
| Alternative Nanobody Names | Anti-Centrosomal Protein Of 164 Kda nanobodyAnti-Cep164 nanobodyAnti-CEP164 nanobodyAnti-KIAA1052 nanobodyAnti-NPHP15 nanobody |
Information sourced from Uniprot.org
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