| Post Translational Modifications | Phosphorylated by PLK1 at Thr-78, creating a self-tethering site that specifically interacts with the polo-box domain of PLK1. |
| Function | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. |
| Protein Name | Centromere Protein UCenp-UCentromere Protein Of 50 KdaCenp-50Interphase Centromere Complex Protein 24Kshv Latent Nuclear Antigen-Interacting Protein 1Mlf1-Interacting ProteinPolo-Box-Interacting Protein 1 |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-606279Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | CytoplasmNucleusChromosomeCentromereKinetochoreLocalizes In The Kinetochore Domain Of CentromeresColocalizes With Plk1 At The Interzone Between The Inner And The Outer Kinetochore Plates |
| Alternative Antibody Names | Anti-Centromere Protein U antibodyAnti-Cenp-U antibodyAnti-Centromere Protein Of 50 Kda antibodyAnti-Cenp-50 antibodyAnti-Interphase Centromere Complex Protein 24 antibodyAnti-Kshv Latent Nuclear Antigen-Interacting Protein 1 antibodyAnti-Mlf1-Interacting Protein antibodyAnti-Polo-Box-Interacting Protein 1 antibodyAnti-CENPU antibodyAnti-ICEN24 antibodyAnti-KLIP1 antibodyAnti-MLF1IP antibodyAnti-PBIP1 antibody |
Information sourced from Uniprot.org
