| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CENPK (1-269) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CENPK |
| Gene ID: |
64105 |
| Uniprot ID: |
CENPK_HUMAN |
| Immunogen Region: |
1-269 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-269 of human CENPK (NP_071428.2). |
| Immunogen Sequence: |
MNQEDLDPDSTTDVGDVTNT EEELIRECEEMWKDMEECQN KLSLIGTETLTDSNAQLSLL IMQVKCLTAELSQWQKKTPE TIPLTEDVLITLGKEEFQKL RQDLEMVLSTKESKNEKLKE DLEREQRWLDEQQQIMESLN VLHSELKNKVETFSESRIFN ELKTKMLNIKEYKEKLLSTL GEFLEDHFPLPDRSVKKKKK NIQESSVNLITLHEMLEILI NRLFDVPHDPYVKISDSFW |
| Tissue Specificity | Detected in several fetal organs with highest levels in fetal liver. In adults, it is weakly expressed in lung and placenta. |
| Function | Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with KNL1 to recruit the NDC80 complex to the outer kinetochore. |
| Protein Name | Centromere Protein KCenp-KInterphase Centromere Complex Protein 37Protein Af-5alphaP33 |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-606279Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | NucleusChromosomeCentromereKinetochoreLocalizes Exclusively In The CentromeresThe Cenpa-Cad Complex Is Probably Recruited On Centromeres By The Cenpa-Nac Complex |
| Alternative Antibody Names | Anti-Centromere Protein K antibodyAnti-Cenp-K antibodyAnti-Interphase Centromere Complex Protein 37 antibodyAnti-Protein Af-5alpha antibodyAnti-P33 antibodyAnti-CENPK antibodyAnti-ICEN37 antibodyAnti-FKSG14 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
