| Tissue Specificity | Detected in several fetal organs with highest levels in fetal liver. In adults, it is weakly expressed in lung and placenta. |
| Function | Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with KNL1 to recruit the NDC80 complex to the outer kinetochore. |
| Protein Name | Centromere Protein KCenp-KInterphase Centromere Complex Protein 37Protein Af-5alphaP33 |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-606279Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | NucleusChromosomeCentromereKinetochoreLocalizes Exclusively In The CentromeresThe Cenpa-Cad Complex Is Probably Recruited On Centromeres By The Cenpa-Nac Complex |
| Alternative Antibody Names | Anti-Centromere Protein K antibodyAnti-Cenp-K antibodyAnti-Interphase Centromere Complex Protein 37 antibodyAnti-Protein Af-5alpha antibodyAnti-P33 antibodyAnti-CENPK antibodyAnti-ICEN37 antibodyAnti-FKSG14 antibody |
Information sourced from Uniprot.org
