| Host: | Mouse |
| Applications: | ELISA/WB/FACS |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal anti-Cellubrevin/VAMP-3 (1-77aa) for use in ELISA, WB and FACS in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Monoclonal |
| Clone ID : | AT4G9 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2bk |
| Formulation: | Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol |
| Purification: | By protein-G affinity chromatography |
| Concentration: | 1 mg/mL |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | VAMP3 |
| Gene ID: | 9341 |
| Uniprot ID: | VAMP3_HUMAN |
| Immunogen Region: | 1-77aa |
| Accession Number: | NP_004772 |
| Immunogen: | Recombinant human cellubrevin (1-77aa) purified from E. coli |
| Post Translational Modifications | Ubiquitinated by RNF167 at Lys-66, Lys-68 and Lys-77, regulating the recycling endosome pathway. (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type B (BoNT/B, botB) which hydrolyzes the 59-Gln-|-Phe-60 bond and probably inhibits neurotransmitter release. (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type D (BoNT/D, botD) which hydrolyzes the 42-Lys-|-Leu-43 bond and probably inhibits neurotransmitter release. Note that humans are not known to be infected by C.botulinum type D. (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type F (BoNT/F, botF) which hydrolyzes the 41-Gln-|-Lys-42 bond and probably inhibits neurotransmitter release. |
| Function | SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. |
| Protein Name | Vesicle-Associated Membrane Protein 3Vamp-3CellubrevinCebSynaptobrevin-3 |
| Database Links | Reactome: R-HSA-1236974Reactome: R-HSA-6811440Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013405Reactome: R-HSA-9013406Reactome: R-HSA-9013407Reactome: R-HSA-9013408Reactome: R-HSA-9013409Reactome: R-HSA-9013423Reactome: R-HSA-9035034 |
| Cellular Localisation | Early Endosome MembraneSingle-Pass Type Iv Membrane ProteinRecycling Endosome MembraneSynapseSynaptosome |
| Alternative Antibody Names | Anti-Vesicle-Associated Membrane Protein 3 antibodyAnti-Vamp-3 antibodyAnti-Cellubrevin antibodyAnti-Ceb antibodyAnti-Synaptobrevin-3 antibodyAnti-VAMP3 antibodyAnti-SYB3 antibody |
Information sourced from Uniprot.org