| Host: | Rabbit |
| Applications: | ELISA/IP/WB |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Cell Surface Glycoprotein MUC18 (330-353) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | FITC |
| Isotype: | IgG |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: | Affinity Purified |
| Concentration: | 0.5-1.5 µg/µl |
| Dilution Range: | WB: 1:2, 500-1:5, 000 ELISA: 1:50, 000 IP: 1:200 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | Mcam |
| Gene ID: | 78967 |
| Uniprot ID: | MUC18_RAT |
| Immunogen Region: | 330-353 |
| Immunogen: | Synthetic peptide taken within amino acid region 330-353 on rat Cell Surface Glycoprotein MUC18 protein. |
| Tissue Specificity | Detected in lung, uterus and placenta (at protein level). Detected in heart, lung, kidney, adrenal gland, intestine, testis, skeletal muscle and aorta. Detected at low levels in adult brain, in particular in brain stem and spinal cord, but also in hippocampus, olfactory bulb and striatum (at protein level). |
| Function | Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. |
| Protein Name | Cell Surface Glycoprotein Muc18 Gicerin Melanoma Cell Adhesion Molecule Melanoma-Associated Antigen Muc18 Cd Antigen Cd146 |
| Database Links | Reactome: R-RNO-8980692 Reactome: -RNO-9013026 Reactome: -RNO-9013149 Reactome: -RNO-9013404 Reactome: -RNO-9013405 Reactome: -RNO-9013408 Reactome: -RNO-9035034 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Perikaryon Detected At The Surface Of The Cell Body Of Motor Neurons |
| Alternative Antibody Names | Anti-Cell Surface Glycoprotein Muc18 antibody Anti-Gicerin antibody Anti-Melanoma Cell Adhesion Molecule antibody Anti-Melanoma-Associated Antigen Muc18 antibody Anti-Cd Antigen Cd146 antibody Anti-Mcam antibody Anti-Muc18 antibody |
Information sourced from Uniprot.org