| Tissue Specificity | Expressed in frontal cortex. Isoform 1 is expressed in brain and lung. Isoform 2 is expressed in heart, brain, placenta, lung, liver, kidney, skeletal muscle and pancreas. Isoform 4 is expressed in heart, lung, skeletal muscle, kidney and pancreas. |
| Function | RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts both as an activator and as a repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury. Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression. Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediately upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA. Binds to an intronic RNA element responsible for the silencing of exon 21 splicing. Binds to (CUG)n repeats. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF1, negatively regulates the processing to mature miRNA. |
| Protein Name | Cugbp Elav-Like Family Member 2Celf-2Bruno-Like Protein 3Cug Triplet Repeat Rna-Binding Protein 2Cug-Bp2Cug-Bp- And Etr-3-Like Factor 2Elav-Type Rna-Binding Protein 3Etr-3Neuroblastoma Apoptosis-Related Rna-Binding ProteinHnaporRna-Binding Protein Brunol-3 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmAccumulates In The Cytoplasm After Ionizing RadiationColocalizes With Apobec1 And A1cfRna-Binding Activity Is Detected In Both Nuclear And Cytoplasmic Compartments |
| Alternative Antibody Names | Anti-Cugbp Elav-Like Family Member 2 antibodyAnti-Celf-2 antibodyAnti-Bruno-Like Protein 3 antibodyAnti-Cug Triplet Repeat Rna-Binding Protein 2 antibodyAnti-Cug-Bp2 antibodyAnti-Cug-Bp- And Etr-3-Like Factor 2 antibodyAnti-Elav-Type Rna-Binding Protein 3 antibodyAnti-Etr-3 antibodyAnti-Neuroblastoma Apoptosis-Related Rna-Binding Protein antibodyAnti-Hnapor antibodyAnti-Rna-Binding Protein Brunol-3 antibodyAnti-CELF2 antibodyAnti-BRUNOL3 antibodyAnti-CUGBP2 antibodyAnti-ETR3 antibodyAnti-NAPOR antibody |
Information sourced from Uniprot.org
