| Host: | Mouse |
| Applications: | WB/IHC/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
| Short Description : | Mouse monoclonal antibody anti-Cyclin-Dependent Kinase Inhibitor 2a (Met1-Asp156) is suitable for use in Western Blot, Immunohistochemistry and ELISA research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 2E5 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | 0.01M PBS |
| Purification: | Protein G purified from mice ascites |
| Concentration: | 1 mg/mL |
| Storage Instruction: | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
| Gene Symbol: | CDKN2A |
| Gene ID: | 1029 |
| Uniprot ID: | CDN2A_HUMAN |
| Immunogen Region: | Met1-Asp156 |
| Immunogen: | E coli-derived recombinant Human CDKN2A/p16INK4a (Met1-Asp156) |
| Post Translational Modifications | Phosphorylation seems to increase interaction with CDK4. |
| Function | Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. |
| Protein Name | Cyclin-Dependent Kinase Inhibitor 2aCyclin-Dependent Kinase 4 Inhibitor ACdk4iMultiple Tumor Suppressor 1Mts-1P16-Ink4aP16-Ink4P16ink4a |
| Database Links | Reactome: R-HSA-111471Reactome: R-HSA-2559580Reactome: R-HSA-2559585Reactome: R-HSA-3108214Reactome: R-HSA-3232118Reactome: R-HSA-6804757Reactome: R-HSA-69541Reactome: R-HSA-8941858Reactome: R-HSA-9645722Reactome: R-HSA-9646303Reactome: R-HSA-9646304Reactome: R-HSA-9759194Reactome: R-HSA-2559582Reactome: R-HSA-69231Reactome: R-HSA-8853884Reactome: R-HSA-9630791Reactome: R-HSA-9630794Reactome: R-HSA-9632697Reactome: R-HSA-9632700Reactome: R-HSA-9825892 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase Inhibitor 2a antibodyAnti-Cyclin-Dependent Kinase 4 Inhibitor A antibodyAnti-Cdk4i antibodyAnti-Multiple Tumor Suppressor 1 antibodyAnti-Mts-1 antibodyAnti-P16-Ink4a antibodyAnti-P16-Ink4 antibodyAnti-P16ink4a antibodyAnti-CDKN2A antibodyAnti-CDKN2 antibodyAnti-MTS1 antibody |
Information sourced from Uniprot.org
