| Host: | Mouse |
| Applications: | WB/IHC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Cyclin-dependent kinase inhibitor 2A (100-156 aa) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | PTR2302 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1k |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range: | WB 1:500-2000 IHC 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CDKN2A |
| Gene ID: | 1029 |
| Uniprot ID: | CDN2A_HUMAN |
| Immunogen Region: | 100-156 aa |
| Specificity: | This antibody detects endogenous levels of p16 INK at Human |
| Immunogen: | Synthesized peptide derived from the human p16 INK at the amino acid range 100-156 |
| Post Translational Modifications | Phosphorylation seems to increase interaction with CDK4. |
| Function | Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. |
| Protein Name | Cyclin-Dependent Kinase Inhibitor 2a Cyclin-Dependent Kinase 4 Inhibitor A Cdk4i Multiple Tumor Suppressor 1 Mts-1 P16-Ink4a P16-Ink4 P16ink4a |
| Database Links | Reactome: R-HSA-111471 Reactome: R-HSA-2559580 Reactome: R-HSA-2559585 Reactome: R-HSA-3108214 Reactome: R-HSA-3232118 Reactome: R-HSA-6804757 Reactome: R-HSA-69541 Reactome: R-HSA-8941858 Reactome: R-HSA-9645722 Reactome: R-HSA-9646303 Reactome: R-HSA-9646304 Reactome: R-HSA-9759194 Reactome: R-HSA-2559582 Reactome: R-HSA-69231 Reactome: R-HSA-8853884 Reactome: R-HSA-9630791 Reactome: R-HSA-9630794 Reactome: R-HSA-9632697 Reactome: R-HSA-9632700 Reactome: R-HSA-9825892 |
| Cellular Localisation | Cytoplasm Nucleus |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase Inhibitor 2a antibody Anti-Cyclin-Dependent Kinase 4 Inhibitor A antibody Anti-Cdk4i antibody Anti-Multiple Tumor Suppressor 1 antibody Anti-Mts-1 antibody Anti-P16-Ink4a antibody Anti-P16-Ink4 antibody Anti-P16ink4a antibody Anti-CDKN2A antibody Anti-CDKN2 antibody Anti-MTS1 antibody |
Information sourced from Uniprot.org