| Tissue Specificity | Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| Post Translational Modifications | Phosphorylated in vitro by CDK5. |
| Function | Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation. Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gTuRC) onto centrosomes. In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery. Required for the recruitment of AKAP9 to centrosomes. Plays a role in neurogenesis. |
| Protein Name | Cdk5 Regulatory Subunit-Associated Protein 2Cdk5 Activator-Binding Protein C48Centrosome-Associated Protein 215 |
| Database Links | Reactome: R-HSA-2565942Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-8854518 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeGolgi ApparatusFound In The Pericentriolar Region Adhering To The Surface Of The Centrosome And In The Region Of The Centrosomal AppendagesLocalizes To Microtubule Plus Ends In The Presence Of Eb1/Mapre1Localization To Centrosomes Versus Golgi Apparatus May Be Cell Type-DependentFor InstanceIn Sk-Br-3 And Hek293f CellsLocalizes To Centrosomes But Not To The Golgi Apparatus |
| Alternative Antibody Names | Anti-Cdk5 Regulatory Subunit-Associated Protein 2 antibodyAnti-Cdk5 Activator-Binding Protein C48 antibodyAnti-Centrosome-Associated Protein 215 antibodyAnti-CDK5RAP2 antibodyAnti-CEP215 antibodyAnti-KIAA1633 antibody |
Information sourced from Uniprot.org
