| Short Description : | Rabbit polyclonal anti-Cyclin-dependent kinase 3 (10-90 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CDK3 |
| Gene ID: | 1018 |
| Uniprot ID: | CDK3_HUMAN |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 10-90 |
| Immunogen Region: | 10-90 aa |
| Specificity: | CDK3 Polyclonal Antibody detects endogenous levels of protein. |
| Function | Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle.involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner. |
| Protein Name | Cyclin-Dependent Kinase 3Cell Division Protein Kinase 3 |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase 3 antibodyAnti-Cell Division Protein Kinase 3 antibodyAnti-CDK3 antibodyAnti-CDKN3 antibody |
Information sourced from Uniprot.org
