| Tissue Specificity | Expressed ubiquitously. Some evidence of isoform-specific tissue distribution. |
| Post Translational Modifications | During FAS- or TNF-induced apoptosis, isoform SV9 is cleaved by caspases to produce p110C, a fragment that contains the C-terminal kinase domain. Phosphorylation at Ser-115 creates a binding site for 14-3-3 proteins. p110C can be autophosphorylated. |
| Function | Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. |
| Protein Name | Cyclin-Dependent Kinase 11bCell Division Cycle 2-Like Protein Kinase 1Clk-1Cell Division Protein Kinase 11bGalactosyltransferase-Associated Protein Kinase P58/GtaPitslre Serine/Threonine-Protein Kinase Cdc2l1P58 Clk-1 |
| Database Links | Reactome: R-HSA-380270 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase 11b antibodyAnti-Cell Division Cycle 2-Like Protein Kinase 1 antibodyAnti-Clk-1 antibodyAnti-Cell Division Protein Kinase 11b antibodyAnti-Galactosyltransferase-Associated Protein Kinase P58/Gta antibodyAnti-Pitslre Serine/Threonine-Protein Kinase Cdc2l1 antibodyAnti-P58 Clk-1 antibodyAnti-CDK11B antibodyAnti-CDC2L1 antibodyAnti-CDK11 antibodyAnti-PITSLREA antibodyAnti-PK58 antibody |
Information sourced from Uniprot.org
