| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CDK11B (1-130) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CDK11B |
| Gene ID: |
984 |
| Uniprot ID: |
CD11B_HUMAN |
| Immunogen Region: |
1-130 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human CDK11B (NP_277021.2). |
| Immunogen Sequence: |
MGDEKDSWKVKTLDEILQEK KRRKEQEEKAEIKRLKNSDD RDSKRDSLEEGELRDHRMEI TIRNSPYRREDSMEDRGEED DSLAIKPPQQMSRKEKAHHR KDEKRKEKRRHRSHSAEGGK HARVKEKERE |
| Tissue Specificity | Expressed ubiquitously. Some evidence of isoform-specific tissue distribution. |
| Post Translational Modifications | During FAS- or TNF-induced apoptosis, isoform SV9 is cleaved by caspases to produce p110C, a fragment that contains the C-terminal kinase domain. Phosphorylation at Ser-115 creates a binding site for 14-3-3 proteins. p110C can be autophosphorylated. |
| Function | Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. |
| Protein Name | Cyclin-Dependent Kinase 11bCell Division Cycle 2-Like Protein Kinase 1Clk-1Cell Division Protein Kinase 11bGalactosyltransferase-Associated Protein Kinase P58/GtaPitslre Serine/Threonine-Protein Kinase Cdc2l1P58 Clk-1 |
| Database Links | Reactome: R-HSA-380270 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase 11b antibodyAnti-Cell Division Cycle 2-Like Protein Kinase 1 antibodyAnti-Clk-1 antibodyAnti-Cell Division Protein Kinase 11b antibodyAnti-Galactosyltransferase-Associated Protein Kinase P58/Gta antibodyAnti-Pitslre Serine/Threonine-Protein Kinase Cdc2l1 antibodyAnti-P58 Clk-1 antibodyAnti-CDK11B antibodyAnti-CDC2L1 antibodyAnti-CDK11 antibodyAnti-PITSLREA antibodyAnti-PK58 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
