| Post Translational Modifications | During apoptosis, induced by Fas or tumor necrosis factor, specific CKD11 p110 isoforms are cleaved by caspases to produce a protein (p110C) that contains the C-terminal kinase domain of the CDK11 proteins. |
| Function | Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression. |
| Protein Name | Cyclin-Dependent Kinase 11aCell Division Cycle 2-Like Protein Kinase 2Cell Division Protein Kinase 11aGalactosyltransferase-Associated Protein Kinase P58/GtaPitslre Serine/Threonine-Protein Kinase Cdc2l2 |
| Database Links | Reactome: R-HSA-380270 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase 11a antibodyAnti-Cell Division Cycle 2-Like Protein Kinase 2 antibodyAnti-Cell Division Protein Kinase 11a antibodyAnti-Galactosyltransferase-Associated Protein Kinase P58/Gta antibodyAnti-Pitslre Serine/Threonine-Protein Kinase Cdc2l2 antibodyAnti-CDK11A antibodyAnti-CDC2L2 antibodyAnti-CDC2L3 antibodyAnti-PITSLREB antibody |
Information sourced from Uniprot.org
