| Host: | Rabbit |
| Applications: | IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Cadherin-23 (61-110 aa) is suitable for use in Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IF 1:200-1:1000ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CDH23 |
| Gene ID: | 64072 |
| Uniprot ID: | CAD23_HUMAN |
| Immunogen Region: | 61-110 aa |
| Specificity: | Cadherin-23 Polyclonal Antibody detects endogenous levels of Cadherin-23 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human CDH23 at the amino acid range 61-110 |
| Function | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. |
| Protein Name | Cadherin-23Otocadherin |
| Database Links | Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Cadherin-23 antibodyAnti-Otocadherin antibodyAnti-CDH23 antibodyAnti-KIAA1774 antibodyAnti-KIAA1812 antibodyAnti-UNQ1894 antibodyAnti-PRO4340 antibody |
Information sourced from Uniprot.org