Anti-CDC45 antibody (1-270) (STJ26198)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CDC45 (1-270) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CDC45 |
| Gene ID | 8318 |
| Uniprot ID | CDC45_HUMAN |
| Immunogen Region | 1-270 |
| Immunogen Sequence | MFVSDFRKEFYEVVQSQRVL LFVASDVDALCACKILQALF QCDHVQYTLVPVSGWQELET AFLEHKEQFHYFILINCGAN VDLLDILQPDEDTIFFVCDT HRPVNVVNVYNDTQIKLLIK QDDDLEVPAYEDIFRDEEED EEHSGNDSDGSEPSEKRTRL EEEIVEQTMRRRQRREWEAR RRDILFDYEQYEYHGTSSAM VMFELAWMLSKDLNDMLWWA IVGLTDQWVQDKITQMKYV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human CDC45 (NP_003495.1). |
Additional Info
| Tissue Specificity | Widely expressed, highest levels are found in adult testis and thymus and in fetal liver. |
| Function | Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. |
| Protein Name | Cell Division Control Protein 45 HomologPorc-Pi-1 |
| Database Links | Reactome: R-HSA-176187Reactome: R-HSA-176974Reactome: R-HSA-68962Reactome: R-HSA-69205 |
| Cellular Localisation | NucleusChromosomeAssociates With Chromatin |
| Alternative Antibody Names | Anti-Cell Division Control Protein 45 Homolog antibodyAnti-Porc-Pi-1 antibodyAnti-CDC45 antibodyAnti-CDC45L antibodyAnti-CDC45L2 antibodyAnti-UNQ374 antibodyAnti-PRO710 antibody |
Information sourced from Uniprot.org