| Short Description : | Mouse monoclonal anti-CD98 for use in FC, IP and IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | FC/IP/IHC-P |
| Host: | Mouse |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | MEM-108 |
| Isotype: | IgG1 |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Dilution Range: | FC 4 µg/ml-IP to be determined-IHC paraffin 10 µg/ml |
| Formulation: | Phosphate buffered saline (PBS) solution with 15 mM sodium azide |
| Storage Instruction: | Store at 2-8°C for up to 1-year, upon receipt. |
| Immunogen: | RAJI human Burkitt's lymphoma cell line |
| Background | CD98 (4F2) is a type II transmembrane glycoprotein which serves as the heavy chain of the heterodimeric amino acid transporters (HATs). CD98, linked to various light chains by disulfide bond, is responsible for cell surface expression and basolateral localization of this transporter complex in polarized epithelial cells and also interacts with beta1 integrins and increases their affinity for ligand. Besides its roles in amino acid transport, CD98 is thus involved in cell fusion and activation. It is implicated in regulation of cellular differentiation, growth and apoptosis. |
Information sourced from Uniprot.org
