Anti-CD93/C1qR antibody [F11] {APC} (STJA0029690)

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STJA0029690
£310.50 - £472.50
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Host: Mouse
Applications: ELISA/FC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-Complement Component C1q Receptor is suitable for use in ELISA and Flow Cytometry research applications.
Clonality : Monoclonal
Clone ID : F11
Conjugation: APC
Isotype: IgG2ak
Formulation: 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.
Purification: Purified
Concentration: 0.5 mg/mL
Storage Instruction: Store at 4°C for 12 months. Protect from light. Do not freeze.
Gene Symbol: CD93
Gene ID: 22918
Uniprot ID: C1QR1_HUMAN
Post Translational Modifications N- and O-glycosylated. Phosphorylated on Tyr-628 and Tyr-644 by SRC.these phosphorylations promote endothelial cell adhesion and migration.
Function Cell surface receptor that plays a role in various physiological processes including inflammation, phagocytosis, and cell adhesion. Plays a role in phagocytosis and enhances the uptake of apoptotic cells and immune complexes by acting as a receptor for defense collagens including surfactant protein A/SFTPA1, C1q, and mannose-binding lectin (MBL2). Plays a role in the regulation of endothelial cell function and adhesion by activating angiogenesis. Mechanistically, exerts its angiogenic function by associating with beta-dystroglycan, leading to SRC-dependent phosphorylation and subsequent recruitment of CBL. In turn, CBL provides a docking site for downstream signaling components, such as CRKL to enhance cell migration. Participates in angiogenesis also by acting as a receptor for the ECM pan-endothelial glycoprotein multimerin-2/MMRN2 and IGFBP7 ligands. Both ligands play a non-redundant role in CD93-mediated endothelial cell function. Acts as a key regulator of endothelial barrier function through modulating VEGFR2 function.
Protein Name Complement Component C1q Receptor
C1q/Mbl/Spa Receptor
C1qr
C1qr(P
C1qrp
Cdw93
Complement Component 1 Q Subcomponent Receptor 1
Matrix-Remodeling-Associated Protein 4
Cd Antigen Cd93
Database Links Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Complement Component C1q Receptor antibody
Anti-C1q/Mbl/Spa Receptor antibody
Anti-C1qr antibody
Anti-C1qr(P antibody
Anti-C1qrp antibody
Anti-Cdw93 antibody
Anti-Complement Component 1 Q Subcomponent Receptor 1 antibody
Anti-Matrix-Remodeling-Associated Protein 4 antibody
Anti-Cd Antigen Cd93 antibody
Anti-CD93 antibody
Anti-C1QR1 antibody
Anti-MXRA4 antibody

Information sourced from Uniprot.org