Anti-CD8a/Lyt2 antibody [243] {FITC} (STJA0027995)

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STJA0027995
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Host: Rat
Applications: FC
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS
Short Description : Rat monoclonal antibody anti-T-Cell Surface Glycoprotein Cd8 Alpha Chain is suitable for use in Flow Cytometry research applications.
Clonality : Monoclonal
Clone ID : 243
Conjugation: FITC
Isotype: lgG2b
Formulation: 0.01M PBS, pH 7.4, 02% BSA, 0.05% Proclin 300
Purification: Purified
Concentration: 05 mg/mL
Storage Instruction: Store at 4°C for 12 months Protect from light Do not freeze
Gene Symbol: Cd8a
Gene ID: 12525
Uniprot ID: CD8A_MOUSE
Function Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
Protein Name T-Cell Surface Glycoprotein Cd8 Alpha Chain
T-Cell Surface Glycoprotein Lyt-2
Cd Antigen Cd8a
Database Links Reactome: R-MMU-198933
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cd8a Localizes To Lipid Rafts Only When Associated With Its Partner Cd8b
Alternative Antibody Names Anti-T-Cell Surface Glycoprotein Cd8 Alpha Chain antibody
Anti-T-Cell Surface Glycoprotein Lyt-2 antibody
Anti-Cd Antigen Cd8a antibody
Anti-Cd8a antibody
Anti-Lyt-2 antibody
Anti-Lyt2 antibody

Information sourced from Uniprot.org