Anti-CD86/B7-2 antibody [GL1] {PE} (STJA0031360)

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STJA0031360
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Host: Rat
Applications: FC
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rat monoclonal antibody anti-T-Lymphocyte Activation antigen Cd86 is suitable for use in Flow Cytometry research applications.
Clonality : Monoclonal
Clone ID : GL1
Conjugation: PE
Isotype: IgG2ak
Formulation: 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.
Purification: Purified
Concentration: 0.5 mg/mL
Storage Instruction: Store at 4°C for 12 months. Protect from light. Do not freeze.
Gene Symbol: Cd86
Gene ID: 12524
Uniprot ID: CD86_MOUSE
Post Translational Modifications Polyubiquitinated.which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.
Function Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation.
Protein Name T-Lymphocyte Activation Antigen Cd86
Activation B7-2 Antigen
Early T-Cell Costimulatory Molecule 1
Etc-1
Cd Antigen Cd86
Database Links Reactome: R-MMU-1257604
Reactome: -MMU-389356
Reactome: -MMU-389357
Reactome: -MMU-389359
Reactome: -MMU-389513
Reactome: -MMU-6811558
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-T-Lymphocyte Activation Antigen Cd86 antibody
Anti-Activation B7-2 Antigen antibody
Anti-Early T-Cell Costimulatory Molecule 1 antibody
Anti-Etc-1 antibody
Anti-Cd Antigen Cd86 antibody
Anti-Cd86 antibody

Information sourced from Uniprot.org