| Host: | Mouse |
| Applications: | FC/IP/WB/IHC-F |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal anti-CD86 for use in FC, IP, WB and IHC-F in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Monoclonal |
| Clone ID : | BU63 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide |
| Purification: | Purified by protein-A affinity chromatography. |
| Concentration: | 1 mg/mL |
| Storage Instruction: | Store at 2-8°C for up to 1-year, upon receipt. |
| Gene Symbol: | CD86 |
| Gene ID: | 942 |
| Uniprot ID: | CD86_HUMAN |
| Immunogen: | B-lymphoblastoid cell line ARH 77 |
| Post Translational Modifications | Polyubiquitinated.which is promoted by MARCH8 and results in endocytosis and lysosomal degradation. |
| Function | Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation. Isoform 2: Interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. (Microbial infection) Acts as a receptor for adenovirus subgroup B. |
| Protein Name | T-Lymphocyte Activation Antigen Cd86Activation B7-2 AntigenB70Bu63Ctla-4 Counter-Receptor B7.2Fun-1Cd Antigen Cd86 |
| Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-2219530Reactome: R-HSA-389356Reactome: R-HSA-389357Reactome: R-HSA-389359Reactome: R-HSA-389513Reactome: R-HSA-6783783Reactome: R-HSA-6811558 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-T-Lymphocyte Activation Antigen Cd86 antibodyAnti-Activation B7-2 Antigen antibodyAnti-B70 antibodyAnti-Bu63 antibodyAnti-Ctla-4 Counter-Receptor B7.2 antibodyAnti-Fun-1 antibodyAnti-Cd Antigen Cd86 antibodyAnti-CD86 antibodyAnti-CD28LG2 antibody |
Information sourced from Uniprot.org
![Anti-CD86 antibody [BU63] (STJ16100509)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/149226/346826/STJ16100509_1__67655.1681998937.jpg?c=1 "Anti-CD86 antibody [BU63] (STJ16100509)")
