| Tissue Specificity | Abundantly expressed in spleen and brain, but is also detected in most tissues analyzed. |
| Function | Transmembrane glycoprotein predominantly found on the surface of many immune cells including dendritic cells or lymphocytes that plays various roles in immune response regulation. Plays an essential role in CD4(+) T-selection, differentiation and stability by regulating the activity of the major E3 ubiquitin ligase responsible for controlling MHC II trafficking MARCHF8. Also inhibits MARCHF1 association with MHC II and ubiquitination of MHCII. In addition, acts as an important modulator of protective responses against acute infections. |
| Protein Name | Cd83 AntigenMcd83Cd Antigen Cd83 |
| Database Links | |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Cd83 Antigen antibodyAnti-Mcd83 antibodyAnti-Cd Antigen Cd83 antibodyAnti-Cd83 antibody |
Information sourced from Uniprot.org
