| Tissue Specificity | Expressed on activated B-cells, macrophages and dendritic cells. |
| Post Translational Modifications | Palmitoylated by ZDHHC20.palmitoylation protects CD80 from ubiquitin-mediated degradation, regulating the protein stability, and ensures its accurate plasma membrane localization. |
| Function | Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation. Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells together with the CD28 receptor which is constitutively expressed on the cell surface of T-cells. In turn, activates different signaling pathways such as NF-kappa-B or MAPK leading to the production of different cytokines. In addition, CD28/CD80 costimulatory signal stimulates glucose metabolism and ATP synthesis of T-cells by activating the PI3K/Akt signaling pathway. Also acts as a regulator of PDL1/PDCD1 interactions to limit excess engagement of PDL1 and its inhibitory role in immune responses. Expressed on B-cells, plays a critical role in regulating interactions between B-cells and T-cells in both early and late germinal center responses, which are crucial for the generation of effective humoral immune responses. (Microbial infection) Acts as a receptor for adenovirus subgroup B. |
| Protein Name | T-Lymphocyte Activation Antigen Cd80Activation B7-1 AntigenBb1Ctla-4 Counter-Receptor B7.1B7Cd Antigen Cd80 |
| Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-2219530Reactome: R-HSA-389356Reactome: R-HSA-389357Reactome: R-HSA-389359Reactome: R-HSA-389513Reactome: R-HSA-6783783Reactome: R-HSA-6811558 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-T-Lymphocyte Activation Antigen Cd80 antibodyAnti-Activation B7-1 Antigen antibodyAnti-Bb1 antibodyAnti-Ctla-4 Counter-Receptor B7.1 antibodyAnti-B7 antibodyAnti-Cd Antigen Cd80 antibodyAnti-CD80 antibodyAnti-CD28LG antibodyAnti-CD28LG1 antibodyAnti-LAB7 antibody |
Information sourced from Uniprot.org
