Anti-CD80/B7-1 antibody [16-10A1] (STJA0027447)

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STJA0027447
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Host: Armenian Hamster
Applications: FC
Reactivity: Mouse/Dog
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Armenian Hamster monoclonal antibody anti-T-Lymphocyte Activation antigen Cd80 is suitable for use in Flow Cytometry research applications.
Clonality : Monoclonal
Clone ID : 16-10A1
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS, pH 7.4.
Purification: Protein A/G purified from cell culture supernatant.
Concentration: 1 mg/ml
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: Cd80
Gene ID: 12519
Uniprot ID: CD80_MOUSE
Function Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation. Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells together with the CD28 receptor which is constitutively expressed on the cell surface of T-cells. In turn, activates different signaling pathways such as NF-kappa-B or MAPK leading to the production of different cytokines. In addition, CD28/CD80 costimulatory signal stimulates glucose metabolism and ATP synthesis of T-cells by activating the PI3K/Akt signaling pathway. Acts also as a regulator of PDL1/PDCD1 interactions to limit excess engagement of PDL1 and its inhibitory role in immune responses. Expressed on B-cells, plays a critical role in regulating interactions between B-cells and T-cells in both early and late germinal center responses, which are crucial for the generation of effective humoral immune responses.
Protein Name T-Lymphocyte Activation Antigen Cd80
Activation B7-1 Antigen
B7
Cd Antigen Cd80
Database Links Reactome: R-MMU-1257604
Reactome: -MMU-389356
Reactome: -MMU-389357
Reactome: -MMU-389359
Reactome: -MMU-389513
Reactome: -MMU-6811558
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-T-Lymphocyte Activation Antigen Cd80 antibody
Anti-Activation B7-1 Antigen antibody
Anti-B7 antibody
Anti-Cd Antigen Cd80 antibody
Anti-Cd80 antibody
Anti-B7 antibody

Information sourced from Uniprot.org