Anti-CD8 antibody [MEM-31] (STJ16100051)

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STJ16100051-01
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Short Description :Mouse monoclonal anti-CD8 for use in FC and IP in Human samples. Datasheet included with dilution recommendations, and related reagents.
Applications:FC/IP
Host:Mouse
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :MEM-31
Isotype:IgG2a
Conjugation:Unconjugated
Concentration:1 mg/mL
Dilution Range:FC 1 µg/ml-IP-Mass Cytometry
Formulation:Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Storage Instruction:Store at 2-8°C for up to 1-year, upon receipt.
Immunogen:Crude thymus membrane fraction.
Background The CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as alpha/beta heterodimer on majority of MHC I-restricted conventional T cells and thymocytes and as alpha/alpha homodimer on subsets of memory T cells, intraepithelial lymphocytes, NK cells and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha-beta but not alpha-alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.

Information sourced from Uniprot.org

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