![Anti-CD8 antibody [MEM-31] {FITC} (STJ16100052)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/148770/346505/STJ16100052_1__12123.1681998533.jpg?c=1 "Anti-CD8 antibody [MEM-31] {FITC} (STJ16100052)")
![Anti-CD8 antibody [MEM-31] {FITC} (STJ16100052)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/148770/346505/STJ16100052_1__12123.1681998533.jpg?c=1 "Anti-CD8 antibody [MEM-31] {FITC} (STJ16100052)")
Anti-CD8 antibody [MEM-31] {FITC} (STJ16100052)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationFITC
IsotypeIgG2a
ImmunogenCrude thymus membrane fraction.
General Information
| Short Description | Mouse monoclonal anti-CD8 for use in FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | MEM-31 |
| Isotype | IgG2a |
| Conjugation | FITC |
| Dilution Range | FC 20 ยตl reagent 100 ยตl of whole blood or 106 cells in a suspension. |
| Formulation | Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide |
| Storage Instruction | Store at 2-8ยฐC for up to 1-year, upon receipt. |
Target Information
| Immunogen | Crude thymus membrane fraction. |
Additional Info
| Background | The CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as alpha/beta heterodimer on majority of MHC I-restricted conventional T cells and thymocytes and as alpha/alpha homodimer on subsets of memory T cells, intraepithelial lymphocytes, NK cells and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha-beta but not alpha-alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling. |
Information sourced from Uniprot.org