| Host: |
Mouse |
| Applications: |
IHC-P |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-CD79b is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
JS01 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1 |
| Formulation: |
Tissue culture supernatant with 15mM sodium azide |
| Dilution Range: |
IHC-P 1:40 |
| Storage Instruction: |
Store at 2-8°C upon receipt. |
| Gene Symbol: |
CD79B |
| Gene ID: |
974 |
| Uniprot ID: |
CD79B_HUMAN |
| Immunogen: |
A recombinant protein containing 48 amino acids of the cytoplasmic domain of the CD79b molecule |
| Tissue Specificity | B-cells. |
| Post Translational Modifications | Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK. |
| Function | Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. |
| Protein Name | B-Cell Antigen Receptor Complex-Associated Protein Beta ChainB-Cell-Specific Glycoprotein B29Ig-BetaImmunoglobulin-Associated B29 ProteinCd Antigen Cd79b |
| Database Links | Reactome: R-HSA-5690714Reactome: R-HSA-9679191Reactome: R-HSA-983695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinFollowing Antigen BindingThe Bcr Has Been Shown To Translocate From Detergent-Soluble Regions Of The Cell Membrane To Lipid Rafts Although Signal Transduction Through The Complex Can Also Occur Outside Lipid Rafts |
| Alternative Antibody Names | Anti-B-Cell Antigen Receptor Complex-Associated Protein Beta Chain antibodyAnti-B-Cell-Specific Glycoprotein B29 antibodyAnti-Ig-Beta antibodyAnti-Immunoglobulin-Associated B29 Protein antibodyAnti-Cd Antigen Cd79b antibodyAnti-CD79B antibodyAnti-B29 antibodyAnti-IGB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
